Endocrine Abstracts

Hypothyroidism refers to a thyroid hormone (TH) deficiency which mainly affects women (10/1 ratio). The higher default incidence in women remains unexplained. Diagnosis of hypothyroidism is based on a single thyroid-stimulating-hormone (TSH) measurement albeit TSH secretion displays pulsatile patterns which are under the positive control of hypothalamic thyrotropin-releasing-hormone (TRH) and negative feedback exerted by THs. Pituitary thyrotrophs form the smallest (2-4%) pitu...